Como utilizar?

• Aplicar uma camada fina de GFC creme uma a duas vezes por dia, massajando suavemente em movimentos circulares até completa absorção.

• Aplicar o creme até que o efeito desejado seja alcançado.

Precauções:

• Só para utilização externa;

• Mantenha fora do alcance de crianças;

• Evite contato com olhos e mucosas;

• No caso de reação alérgica pare a aplicação do creme;

• Manter o GFC creme à temperatura ambiente.

INCN ingredientes do creme:

 

AQUA
CAPRYLIC/CAPRIC TRIGLYCERIDE
CETEARYL ALCOHOL
ISOPROPYL MYRISTATE
TOCOPHERYL ACETATE
LACTOSE
PHENOXYETHANOL
ETHYLHEXYLGLYCERIN
TOCOPHEROL
CETEARETH-25
BENZYL ALCOHOL
CARBOMER
TRIETHANOLAMINE
SODIUM CITRATE
LACTIC ACID
LACTOSE
WHEY PROTEIN

 

Referências.

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2008;20(3):195-200.
3. Gkogkolou P, Bohm M. Advanced glycation end products: Key players in skin aging? Dermatoendocrinol. 2012;4(3):259-70.
4. Krieg T, Aumailley M. The extracellular matrix of the derm is: flexible structures with dynamic functions. Exp Dermatol.
2011;20(8):689-95.
5. Wilgus TA. Growth Factor – Extracellular Matrix Interactions Regulate Wound Repair. Adv Wound Care (New Rochelle). 2012;1(6):249-54.
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7. Fisher GJ, Kang S, Varani J, et al. Mechanisms of photoaging and chronological skin aging. Arch Dermatol. 2002;138(11):1462-70.
8. Jeanmaire C, Danoux L, Pauly G. Glycation during human dermal intrinsic and actinic ageing: an in vivo and in vitro model study. Br J Dermatol. 2001;145(1):10-8.
9. Quan T. Qin Z, Xia W, et al. Matrix-degrading metalloproteinases in photoaging. J lnvestig Dermatol Symp Proc. 2009;14(1):20-4.
10. Fagot D, Asselineau D, Bernerd F. Matrix metalloproteinase-1 production observed after solar-simulated radiation exposure is assumed by dermal fibroblasts but involves a paracrine activation through epidermal keratinocytes. Photochem Photobiol. 2004;79(6):499-505.
12. Werner S, Grose R. Regulation of wound healing by groW1h factors and cytokines. Physiol Rev. 2003;83(3):835-70.
13. Goldman R. Growth factors and chronic wound healing: past, present, and future. Adv Skin Wound Care. 2004;17(1):24-35.
14. Bhora FY, Dunkin BJ, Batzri S, et al. Effect of groW1h factors on cell proliferation and epithelialization in human skin. J Surg Res.1995;59(2) :236-44.
15. Pastore S, Mascia F, Mariani V. et al. The epidermal growth factor receptor system in skin repair and inflammation . J Invest Dermatol.2008;128(6):1365-74.
16. Johnson KE, Wilgus TA. Vascular Endothelial Growth Factor and Angiogenesis in the Regulation of Cutaneous Wound Repair. Adv Wound Care (New Rochelle). 2014;3(10):647-61.
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21. Cai J L, Li M, Na YQ. Correlation between hyaluronic acid,hyaluronic Acid synthase and human renal clear cell carcinoma. Chin J Cancer Res. 2011;23(1):59-63.
22. Hardwicke J, Schmaljohann D, Boyce D, et al. Epidermal growth factor therapy and wound healing- past, present and future perspectives. Surgeon. 2008;6(3):172-7.
23. Gartner MH, Benson JD, Caldwell MD. Insulin-like growth factors I and II expression in the healing wound. J Surg Res. 1992;52(4) :389-94.
24. Svegliati-Baroni G, Ridolfi F, Di Sario A. et al. Insulin and insulin-like growth factor-1 stimulate proliferation and type I collagen accumulation by human hepatic stellate cells: differential effects on signal transduction pathways. Hepatology. 1999;29(6) :1743-51.
25. Mueller RV, Hunt TK, Tokunaga A. et al. The effect of insulin-like growth factor I on wound healing variables and macrophages in rats. Arch Surg. 1994;129(3):262-5.
28. An JJ, Eum WS, Kwon HS, et al. Protective effects of skin permeable epidermal and fibroblast groW1h factor against ultraviolet­ induced skin damage and human skin wrinkl es. J Cosmet Dermatol. 2013;12(4):287-95.
29. Sundaram H, Mehta RrnebC, Norine J A, et al. Topically applied physiologically balanced growht factors: a new paradigm of skin rejuvenation. J Drugs Dermatol. 2009;8(5 Suppl Skin Rejuvenation):4-13.
30. Available at: http:// www.independentchemical.com/ adminimg/product pdf/15415739261544256163bio-placenta.pdf Accessed March 9, 2017.
31. Website de Dermenet NZ all about the Skin article “Role of growth factors in skin creams: Author: Anoma Ranaweera Medical Writer. Auckland, New Zealand, DermNet NZ Editor-in-Chief: Dr. Amanda Oaekly, Dermatologist, Hamilton, NewZealand 2011. Update January 2019
32. Website life extension magazine Science & Research I Magazine I 2017 I June I Topical Growth Factors Orchestrate Skin Repair

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